New dual-comb functional Near Infrared Spectroscopy (fNIRS) technique: study of optical properties and perturbation localization

Roberto Barreiro; Frank Sanabria; Pedro Martín-Mateos; J. L. González-Mora; J. E. Posada-Román; Cristina de Dios

doi:10.1117/12.2647387

14 March 2023 New dual-comb functional Near Infrared Spectroscopy (fNIRS) technique: study of optical properties and perturbation localization

Roberto Barreiro, Frank Sanabria, Pedro Martín-Mateos, J. L. González-Mora, J. E. Posada-Román, Cristina de Dios

Author Affiliations +

Proceedings Volume 12365, Neural Imaging and Sensing 2023; 1236506 (2023) https://doi.org/10.1117/12.2647387
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present a new functional near infrared spectroscopy (fNIRs) technique based on dual-comb optical interrogation applied to dispersive media (DC-fNIRS) that can retrieve the frequency response of a living tissue (such as the brain) by parallel sampling of its frequency response in amplitude and phase at specific frequencies. With this information, we can retrieve the impulse response (diffuse-time-of-flight measurements, DTOF) of the medium and extract the absolute optical properties of the tissue and the spatial localization of perturbations for functional analysis with millisecond temporal resolution and noiseless optical gain, increasing the penetration. We have tested these predictions studying a biomimetic phantom with the same optical characteristics as brain tissue confirming the capacities of the DC-fNIRs technique for diffuse media. The system is patent pending PCT/ES2022/070176.

Conference Presentation

Citation Download Citation

Roberto Barreiro, Frank Sanabria, Pedro Martín-Mateos, J. L. González-Mora, J. E. Posada-Román, and Cristina de Dios "New dual-comb functional Near Infrared Spectroscopy (fNIRS) technique: study of optical properties and perturbation localization", Proc. SPIE 12365, Neural Imaging and Sensing 2023, 1236506 (14 March 2023); https://doi.org/10.1117/12.2647387

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available