Deciphering the efficacy of antiplatelet drugs under vascular stenosis by high-speed on-chip optofluidic imaging

Yunjie Deng; Hui Min Tay; Yuqi Zhou; Xueer Fei; Masako Nishikawa; Ting-Hui Xiao; Yutaka Yatomi; Han Wei Hou; Keisuke Goda

doi:10.1117/12.2656006

16 March 2023 Deciphering the efficacy of antiplatelet drugs under vascular stenosis by high-speed on-chip optofluidic imaging

Yunjie Deng, Hui Min Tay, Yuqi Zhou, Xueer Fei, Masako Nishikawa, Ting-Hui Xiao, Yutaka Yatomi, Han Wei Hou, Keisuke Goda

Author Affiliations +

Proceedings Volume 12390, High-Speed Biomedical Imaging and Spectroscopy VIII; 123900A (2023) https://doi.org/10.1117/12.2656006
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Vascular stenosis caused by atherosclerosis can lead to platelet activation and aggregation in thrombosis. However, the efficacy of antiplatelet drugs under stenosis is not well understood due to the lack of analytical tools. Here we demonstrate a new method combining optofluidic time-stretch quantitative phase microscopy and a 3D stenosis chip to enable highspeed, high-resolution, label-free imaging of circulating platelet aggregates under atherogenic flow conditions. Interestingly, our findings indicate that the proposed high-speed on-chip optofluidic imaging is a powerful tool for studying platelet biology, antiplatelet drug screening, and developing therapeutic strategies for patients with atherosclerotic diseases.

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Yunjie Deng, Hui Min Tay, Yuqi Zhou, Xueer Fei, Masako Nishikawa, Ting-Hui Xiao, Yutaka Yatomi, Han Wei Hou, and Keisuke Goda "Deciphering the efficacy of antiplatelet drugs under vascular stenosis by high-speed on-chip optofluidic imaging", Proc. SPIE 12390, High-Speed Biomedical Imaging and Spectroscopy VIII, 123900A (16 March 2023); https://doi.org/10.1117/12.2656006

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