Hollow MnO2 for tumor-targeting chemo-photodynamic therapy for melanoma

Zhili Shui; Yutong Zheng

doi:10.1117/12.2660310

6 December 2022 Hollow MnO₂ for tumor-targeting chemo-photodynamic therapy for melanoma

Zhili Shui, Yutong Zheng

Proceedings Volume 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022); 1245816 (2022) https://doi.org/10.1117/12.2660310
Event: International Conference on Biomedical and Intelligent Systems, 2022, Chengdu, China

Abstract

Hollow manganese dioxide (H-MnO₂) has been a popular nano-platform in widespread applications, and the extraordinary properties of H-MnO₂ include the high capacity for drug loading and the unique ability to adjust hypoxic tumor microenvironment (TME), which plays a significant role in treating the tumor. Herein, the H-MnO₂ structure was prepared by using the silica as a template. The H-MnO₂ would then be co-loaded with a chemotherapy drug temozolomide (TMZ) and a photodynamic agent IR780. In addition, the H-MnO₂ was coated with polyethylene glycol (PEG) and modified with RGD peptide sequence (ACDCRGDCFCG) to achieve high stabilization and targeting therapy. In short, the resulted TMZ/IR780/H-MnO2@PEG-RGD would be a promising nanoparticle to treat melanoma through the combined chemo-photodynamic therapy and adjustment to hypoxic TME.

Citation Download Citation

Zhili Shui and Yutong Zheng "Hollow MnO₂ for tumor-targeting chemo-photodynamic therapy for melanoma", Proc. SPIE 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022), 1245816 (6 December 2022); https://doi.org/10.1117/12.2660310

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