All-optical multimode fibre photoacoustic endomicroscopy with scalable spatial resolution and field-of-view

Tianrui Zhao; Truc T. Pham; Christian Baker; Michelle T. Ma; Sebastien Ourselin; Tom Vercauteren; Edward Zhang; Paul C. Beard; Wenfeng Xia

doi:10.1117/12.2670411

11 August 2023 All-optical multimode fibre photoacoustic endomicroscopy with scalable spatial resolution and field-of-view

Tianrui Zhao, Truc T. Pham, Christian Baker, Michelle T. Ma, Sebastien Ourselin, Tom Vercauteren, Edward Zhang, Paul C. Beard, Wenfeng Xia

Author Affiliations +

Proceedings Volume 12631, Opto-Acoustic Methods and Applications in Biophotonics VI; 126310M (2023) https://doi.org/10.1117/12.2670411
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

An all-optical, forward-viewing, optical-resolution photoacoustic endomicroscopy probe was developed for guiding minimally invasive procedures. The probe comprises a multimode fibre for the delivery of excitation laser via wavefront shaping, and a fibre-optic ultrasound sensor based on a plane-concave microresonator at the tip of a single-mode fibre. High-resolution photoacoustic microscopy images of mouse red blood cells and mouse ear vasculature were acquired, and the high scalability of the probe in terms of field-of-view and spatial resolution was demonstrated. The ultrathin photoacoustic endomicroscopy probe promises to guide minimally invasive surgery by providing both molecular and microstructural information.

Citation Download Citation

Tianrui Zhao, Truc T. Pham, Christian Baker, Michelle T. Ma, Sebastien Ourselin, Tom Vercauteren, Edward Zhang, Paul C. Beard, and Wenfeng Xia "All-optical multimode fibre photoacoustic endomicroscopy with scalable spatial resolution and field-of-view", Proc. SPIE 12631, Opto-Acoustic Methods and Applications in Biophotonics VI, 126310M (11 August 2023); https://doi.org/10.1117/12.2670411

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available