Computational 3D resolution enhancement for optical coherence tomography with a narrowband visible light source

Jos de Wit; George-Othon Glentis; Jeroen Kalkman

doi:10.1117/12.2670226

11 August 2023 Computational 3D resolution enhancement for optical coherence tomography with a narrowband visible light source

Jos de Wit, George-Othon Glentis, Jeroen Kalkman

Author Affiliations +

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 126321E (2023) https://doi.org/10.1117/12.2670226
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Phase-preserving Spectral Estimation Optical Coherence Tomography (SE-OCT) enables combining axial resolution improvement with computational Depth of Focus (DOF) extension. We combine SE-OCT with Interferometric Synthetic Aperture Microscopy (ISAM) to obtain a high 3D resolution over a large depth range with a narrow bandwidth visible light Super-Luminescent Diode (SLD). SE-OCT gives a five times axial resolution improvement to 1.5 micrometer. The combination with ISAM gives a sub-micron lateral resolution over a 300-micrometer axial range, 12 times the conventional DOF. The results show that phase-preserving SE-OCT is sufficiently accurate for coherent post-processing, enabling the use of cost-effective SLDs in the visible light range for high spatial resolution.

Citation Download Citation

Jos de Wit, George-Othon Glentis, and Jeroen Kalkman "Computational 3D resolution enhancement for optical coherence tomography with a narrowband visible light source", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 126321E (11 August 2023); https://doi.org/10.1117/12.2670226

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