Enhancing laser speckle contrast imaging based on adaptive scale and directional kernel during V-PDT

Chenfei Ren; Tianlong Chen; Miao Chen; Yi Shen; Buhong Li

doi:10.1117/12.2683138

18 July 2023 Enhancing laser speckle contrast imaging based on adaptive scale and directional kernel during V-PDT

Chenfei Ren, Tianlong Chen, Miao Chen, Yi Shen, Buhong Li

Proceedings Volume 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023); 1274509 (2023) https://doi.org/10.1117/12.2683138
Event: Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 2023, Haikou, China

Abstract

Laser Speckle Contrast Imaging (LSCI) as the advantages of high speed, wide field of view, and ease of implementation has been widely used for imaging blood flow and vascular deformation during Vascular targeted Photodynamic Therapy (V-PDT). However, uncorrected direction and or scale kernel failed to improve the visualization of blood vessels derived from poor Signal Noise Ratio (SNR) of micro vessels during V-PDT. In this study, we extracted the adaptive scale and directional kernel using dual-wavelength reflection imaging to enhance laser speckle imaging. The in vivo data showed that the proposed method improved the 4%-29% performance of contrast-to-noise ratio (CNR) and provide a powerful monitoring tool for blood flow and vascular deformation during V-PDT.

Citation Download Citation

Chenfei Ren, Tianlong Chen, Miao Chen, Yi Shen, and Buhong Li "Enhancing laser speckle contrast imaging based on adaptive scale and directional kernel during V-PDT", Proc. SPIE 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 1274509 (18 July 2023); https://doi.org/10.1117/12.2683138

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KEYWORDS

Laser speckle contrast imaging

Speckle

Blood vessels

Blood circulation

Image enhancement

Tissues

Optical filters

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