Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents

Bingyao Tan; Huakun Li; Yueming Zhuo; Le Han; Rajeshkumar Mupparapu; Veluchamy Amutha Barathi; Daniel Palanker; Leopold Schmetterer; Tong Ling

doi:10.1117/12.3003655

12 March 2024 Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents

Bingyao Tan, Huakun Li, Yueming Zhuo, Le Han, Rajeshkumar Mupparapu, Veluchamy Amutha Barathi, Daniel Palanker, Leopold Schmetterer, Tong Ling

Author Affiliations +

Proceedings Volume 12824, Ophthalmic Technologies XXXIV; 1282405 (2024) https://doi.org/10.1117/12.3003655
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Small animals, such as rodents, are attractive options for investigating the intrinsic process of retinal degeneration. In this study, we used phase-sensitive optical coherence tomography to explore the comprehensive dynamics of rats’ outer retinas in response to visual stimuli. By calculating the temporal phase difference between different outer retinal bands, we revealed highly reproducible retinal dynamics, on the order of tens of nanometers, related to different parts of the outer retina. Our approach may pave the way for preclinical optoretinography study in small animals, facilitating clinical translations for the early detection of neurodegenerative diseases.

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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Bingyao Tan, Huakun Li, Yueming Zhuo, Le Han, Rajeshkumar Mupparapu, Veluchamy Amutha Barathi, Daniel Palanker, Leopold Schmetterer, and Tong Ling "Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents", Proc. SPIE 12824, Ophthalmic Technologies XXXIV, 1282405 (12 March 2024); https://doi.org/10.1117/12.3003655

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