Adaptive vessel tracing and segmentation in OCT enables robust quantification of blood vessel wall-to-lumen ratio in the retina

Tobiloba Adejumo; Guangying Ma; Taeyoon Son; Tae-Hoon Kim; David Le; Albert K. Dadzie; Shaiban Ahmed; Xincheng Yao

doi:10.1117/12.2692987

12 March 2024 Adaptive vessel tracing and segmentation in OCT enables robust quantification of blood vessel wall-to-lumen ratio in the retina

Tobiloba Adejumo, Guangying Ma, Taeyoon Son, Tae-Hoon Kim, David Le, Albert K. Dadzie, Shaiban Ahmed, Xincheng Yao

Author Affiliations +

Proceedings Volume 12824, Ophthalmic Technologies XXXIV; 128240I (2024) https://doi.org/10.1117/12.2692987
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

The wall-to-lumen ratio (WLR) of retinal blood vessels promises a sensitive marker for functional assessment of eye conditions. However, in vivo measurement of vessel wall thickness and lumen diameter is still technically challenging, hindering the wide application of WLR in research and clinical settings. In this study, we demonstrate the feasibility of using optical coherence tomography (OCT) as one practical method for in vivo quantification of WLR in the retina. Based on three-dimensional vessel tracing, lateral en face and axial B-scan profiles of individual vessels were constructed. By employing adaptive depth segmentation that traces each blood vessel for en face OCT projection, the vessel wall thickness and lumen diameter could be reliably quantified. A comparative study of control and 5xFAD mice confirmed WLR as a sensitive marker of the eye condition.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Tobiloba Adejumo, Guangying Ma, Taeyoon Son, Tae-Hoon Kim, David Le, Albert K. Dadzie, Shaiban Ahmed, and Xincheng Yao "Adaptive vessel tracing and segmentation in OCT enables robust quantification of blood vessel wall-to-lumen ratio in the retina", Proc. SPIE 12824, Ophthalmic Technologies XXXIV, 128240I (12 March 2024); https://doi.org/10.1117/12.2692987

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available