An implantable optoelectronic probe for monitoring brain tissue oxygenation

Xue Cai; Xing Sheng

doi:10.1117/12.2691552

13 March 2024 An implantable optoelectronic probe for monitoring brain tissue oxygenation

Xue Cai, Xing Sheng

Proceedings Volume 12828, Neural Imaging and Sensing 2024; 1282809 (2024) https://doi.org/10.1117/12.2691552
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The monitoring of partial pressure of oxygen in brain tissue (PbtO₂) holds paramount importance in both neuroscience research and the management of brain-related disorders. While imaging techniques offer avenues to directly or indirectly assess brain oxygenation, their applicability is limited in the study of certain disease models involving behaving animals. Here, we present an optoelectronic probe for real-time and continuous PbtO₂ monitoring, offering wireless capabilities and providing high temporal and spatial resolutions. This probe measures oxygen partial pressure (PO₂) through phosphorescence quenching, and the implantable probe integrates a micro-scale violet light-emitting diode (LED), a thin-film filter, a micro-scale photodetector, and an oxygen-sensing film. An implantable optoelectronic probe and a wireless control circuit miniaturized to centimeter scales form a system for monitoring PbtO₂. Implanted into the brain of rats, this battery-free system demonstrates efficacy in capturing PbtO₂ changes in response to alterations in the fraction of inspired oxygen (FiO₂).

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Xue Cai and Xing Sheng "An implantable optoelectronic probe for monitoring brain tissue oxygenation", Proc. SPIE 12828, Neural Imaging and Sensing 2024, 1282809 (13 March 2024); https://doi.org/10.1117/12.2691552

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