Optical fiber-based LSPR biosensor for enhanced dopamine detection: advancing personalized healthcare

Prabha Shankar Sharma; Kuldeep Choudhary; Vivek Kumar Gupta; Sanjeev Kumar Raghuwanshi; Santosh Kumar

doi:10.1117/12.2691323

12 March 2024 Optical fiber-based LSPR biosensor for enhanced dopamine detection: advancing personalized healthcare

Prabha Shankar Sharma, Kuldeep Choudhary, Vivek Kumar Gupta, Sanjeev Kumar Raghuwanshi, Santosh Kumar

Proceedings Volume 12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV; 1283506 (2024) https://doi.org/10.1117/12.2691323
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Dopamine, a vital neurotransmitter in the human body, plays a crucial role in various physiological functions and is closely associated with neurological disorders such as Parkinson's disease. Timely and accurate detection of dopamine levels is essential for effective disease management and personalized healthcare. In this study, we propose an innovative optical fiber-based biosensor utilizing the Localized Surface Plasmon Resonance (LSPR) effect for highly sensitive and selective dopamine detection. The biosensor probe is fabricated using a SMS (Single mode fiber-Multimode fiber-Single mode fiber) optical fiber structure, which is chemically modified to enhance the LSPR effect. Gold nanoparticles are employed to amplify the plasmonic response, enabling improved sensing performance. Experimental analysis is performed using dopamine samples, and the results are obtained using a spectrometer. The developed LSPR biosensor demonstrates great potential for precise and efficient dopamine detection, paving the way for advanced personalized healthcare and improved management of neurological disorders.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Prabha Shankar Sharma, Kuldeep Choudhary, Vivek Kumar Gupta, Sanjeev Kumar Raghuwanshi, and Santosh Kumar "Optical fiber-based LSPR biosensor for enhanced dopamine detection: advancing personalized healthcare", Proc. SPIE 12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV, 1283506 (12 March 2024); https://doi.org/10.1117/12.2691323

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