Conjugates of DNA and plasmonic nanoparticles for the development of an SPR sensor for nucleic acids

Maria Y. Berezovskaya; Pavel V. Filatov; Polina S. Luganskaja; Alexandra V. Afanasjeva; Daria A. Gorbenko; Maria D. Rubel; Daler R. Dadadzhanov; Tigran A. Vartanyan

doi:10.1117/12.3022750

20 June 2024 Conjugates of DNA and plasmonic nanoparticles for the development of an SPR sensor for nucleic acids

Maria Y. Berezovskaya, Pavel V. Filatov, Polina S. Luganskaja, Alexandra V. Afanasjeva, Daria A. Gorbenko, Maria D. Rubel, Daler R. Dadadzhanov, Tigran A. Vartanyan

Author Affiliations +

Proceedings Volume 13008, Biophotonics in Point-of-Care III; 130080U (2024) https://doi.org/10.1117/12.3022750
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Detection of nucleic acids has become a promising approach in diagnostics, but current methods often have limitations such as the need for expensive equipment or reduced sensitivity and specificity. Tuberculosis caused by M. tuberculosis is a widespread infectious disease that is also prone to developing antibiotic resistance. In this study, we introduce a novel method for detection and genotyping of M. tuberculosis using a biosensor based on a four-way junction (4WJ) DNA probe and plasmon Au nanospheres.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Maria Y. Berezovskaya, Pavel V. Filatov, Polina S. Luganskaja, Alexandra V. Afanasjeva, Daria A. Gorbenko, Maria D. Rubel, Daler R. Dadadzhanov, and Tigran A. Vartanyan "Conjugates of DNA and plasmonic nanoparticles for the development of an SPR sensor for nucleic acids", Proc. SPIE 13008, Biophotonics in Point-of-Care III, 130080U (20 June 2024); https://doi.org/10.1117/12.3022750

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