Paper
1 February 2024 Synthesis, modification, and cellular uptake of metal-organic frameworks as drug carriers
Yulin Li, Yan Sun
Author Affiliations +
Proceedings Volume 13068, Fifth International Conference on Optoelectronic Science and Materials (ICOSM 2023); 130681W (2024) https://doi.org/10.1117/12.3016228
Event: Fifth International Conference on Optoelectronic Science and Materials (ICOSM 2023), 2023, Hefei, China
Abstract
Metal-organic frameworks ( MOF ) are nanoporous materials formed by bridging metal ions and organic connectors. Because of its clear structure, high porosity, high specific surface area, low density, and strong biocompatibility, it has been widely used in biomedical research and as a drug carrier in recent years. However, whether it is completely excreted when used as a drug carrier and whether it has potential toxicity to the human body is still under further study.

In this paper, a new type of MOF material was successfully designed and synthesized with carbon quantum dots ( CDs ) as the core for the visualization of metal-organic framework materials ( MOFs ). The material uses CDs with stable fluorescence properties as the core to synthesize a water-stable metal-organic framework ZIF-8, namely CDs @ZIF-8, which maintains the complete framework structure of ZIF-8 and has fluorescence visualization characteristics.

Cell uptake studies of colon cancer cells using CDs@ZIF-8 nanoparticles and ZIF-8 nanoparticles carrying chemical fluorescence. The results show that CDs@ZIF-8 has stronger and more stable fluorescence characteristics, which lays a material foundation for the visualization of nanodrug carriers and the study of tracking the metabolic process of MOF in vivo, which is innovative and has practical value.
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
Yulin Li and Yan Sun "Synthesis, modification, and cellular uptake of metal-organic frameworks as drug carriers", Proc. SPIE 13068, Fifth International Conference on Optoelectronic Science and Materials (ICOSM 2023), 130681W (1 February 2024); https://doi.org/10.1117/12.3016228
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KEYWORDS
Quantum experiments

Carbon

Cadmium sulfide

Quantum dots

Fluorescence

Micro optical fluidics

Materials properties

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