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20 November 2024 Detection of methotrexate molecules in human plasma by SERS method
Elizaveta A. Demishkevich, Svetlana Doktorova, Andrey Zyubin, Vladimir Rafalskiy, Alexander Zozulya, Anna Kundalevich, Denis Evtifeev, Ivan Lyatun, Ilya Samusev
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Proceedings Volume 13242, Optics in Health Care and Biomedical Optics XIV; 132421F (2024) https://doi.org/10.1117/12.3036059
Event: SPIE/COS Photonics Asia, 2024, Nantong, Jiangsu, China
Abstract
This study demonstrates the possibility of using the SERS method to detect methotrexate (MTX) molecules in the blood plasma of patients in concentrations up to 10-6 M. The paper performs investigation for samples from patients who took the drug at different doses. Borosilicate glasses coated with silver nanoparticles were used as the surface. We analyzed the differences between the spectra of patients after taking medication and healthy volunteers without taking medication. The characteristic maxima of methotrexate were determined.
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Elizaveta A. Demishkevich, Svetlana Doktorova, Andrey Zyubin, Vladimir Rafalskiy, Alexander Zozulya, Anna Kundalevich, Denis Evtifeev, Ivan Lyatun, and Ilya Samusev "Detection of methotrexate molecules in human plasma by SERS method", Proc. SPIE 13242, Optics in Health Care and Biomedical Optics XIV, 132421F (20 November 2024); https://doi.org/10.1117/12.3036059
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KEYWORDS
Nanoparticles
Plasma
Surface enhanced Raman spectroscopy
Vibration
Raman spectroscopy
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