Clinical fluorescence diagnosis of human bladder carcinoma following low-dose photofrin injection

Luc Baert M.D.; Roger Berg; B. van Damme; Marie-Ange D'Hallewin M.D.; Jonas Johansson; Katarina Svanberg M.D.; Sune Svanberg

doi:10.1117/12.48219

1 November 1991 Clinical fluorescence diagnosis of human bladder carcinoma following low-dose photofrin injection

Luc Baert M.D., Roger Berg, B. van Damme, Marie-Ange D'Hallewin M.D., Jonas Johansson, Katarina Svanberg M.D., Sune Svanberg

Author Affiliations +

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48219
Event: MedTech '91, 1991, Berlin, Germany

Abstract

A point-monitoring fluorescence diagnostic system based on a low-energy pulsed laser, fiber transmission optics, and an optical multichannel analyzer was used for diagnosis of patients with bladder malignancies. Twenty-four patients with bladder carcinoma, carcinoma in situ, and/or dysplasia were injected with Photofrin (0.35 or 0.5 mg/kg body weight) 48 hours prior to the investigation. The ratio between the red sensitizer emission and the bluish tissue autofluorescence provided excellent demarcation between papillary tumors and normal bladder wall. Certain cases of dysplasia could be also be differentiated from normal mucosa. Benign exofytic lesion such as malakoplakia appeared different from malignant tumors in fluorescence. Flat suspicious bladder mucosa such as that seen in infectious diseases or after radiation therapy appeared normal in terms of fluorescence.

Citation Download Citation

Luc Baert M.D., Roger Berg, B. van Damme, Marie-Ange D'Hallewin M.D., Jonas Johansson, Katarina Svanberg M.D., and Sune Svanberg "Clinical fluorescence diagnosis of human bladder carcinoma following low-dose photofrin injection", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48219

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available