Arterial healing response after angioplasty and its contributions to restenosis

Cornelius Borst M.D.; Lieselotte van Erven; Evelyn Velema; Mark J. Post

doi:10.1117/12.137308

28 August 1992 Arterial healing response after angioplasty and its contributions to restenosis

Cornelius Borst M.D., Lieselotte van Erven, Evelyn Velema, Mark J. Post

Proceedings Volume 1642, Diagnostic and Therapeutic Cardiovascular Interventions II; (1992) https://doi.org/10.1117/12.137308
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Balloon angioplasty of coronary obstructions is limited by a 40% angiographic restenosis rate six months after the intervention. Myointimal hyperplasia is a major contributor to restenosis. In 77 normal rabbits we examined the question whether severe thermal interventional injury to the iliac artery wall would result in less myointimal hyperplasia than severe mechanical injury induced by balloon dilation. Eight weeks after percutaneous injury by electrical spark erosion, the metal laser probe, cw Nd:YAG laser energy through the sapphire contact probe, 90 degree(s)C RF heated balloon dilation, or standard balloon dilation the neointima thickness measured up to 380 micrometers . When thermally and mechanically damaged walls were compared, myointimal hyperplasia was similar. We conclude that in the normal rabbit the arterial wall healing response after any injury is neointima formation which is the vessel wall's expression of the general pattern of wound healing. It is inferred that alternative modes of injury in new recanalization techniques will lead to induced restenosis rates.

Citation Download Citation

Cornelius Borst M.D., Lieselotte van Erven, Evelyn Velema, and Mark J. Post "Arterial healing response after angioplasty and its contributions to restenosis", Proc. SPIE 1642, Diagnostic and Therapeutic Cardiovascular Interventions II, (28 August 1992); https://doi.org/10.1117/12.137308

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