Development of procedures and instrumentation for use of the Nd:YAG laser in the ablation of metastases from colorectal cancer

Kenneth Eugene Bartels D.V.M.; Mark H. Mellow; Marilyn Kostolich D.V.M.; George A. Henry D.V.M.; Bradley R. Barnes; Frederic M. Durville; Steven A. Schafer; Jerzy S. Krasinski; Richard C. Powell

doi:10.1117/12.137335

1 June 1992 Development of procedures and instrumentation for use of the Nd:YAG laser in the ablation of metastases from colorectal cancer

Kenneth Eugene Bartels D.V.M., Mark H. Mellow, Marilyn Kostolich D.V.M., George A. Henry D.V.M., Bradley R. Barnes, Frederic M. Durville, Steven A. Schafer, Jerzy S. Krasinski, Richard C. Powell

Author Affiliations +

Proceedings Volume 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III; (1992) https://doi.org/10.1117/12.137335
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

While many colon cancers are curable, curability relates closely to stage. Once disease is spread beyond the confines of the colon and adjacent lymph nodes, cure is clearly the exception rather than the rule. Recently, surgical resection of solitary liver metastases has been effective in treatment of colon cancer, producing long term survival in approximately 20% of treatable patients. Surgery, however, is technically complex and there is a high perioperative morbidity and substantial perioperative mortality. For patients with multiple hepatic metastases in whom surgical extirpation is not possible, the outlook is dismal. Other modalities including chemotherapy have also resulted in limited success. Recently, a number of investigators have evaluated the effect of low power interstitial Nd:YAG laser irradiation for inducing hyperthermia and coagulative necrosis is hepatic tissue. In treating multiple or large hepatic metastases, the use of a lower power (1 - 5 watts), long duration (50 - 2400 seconds), single fiber laser delivery system has limitations. A computer controlled continuous wave Nd:YAG (1064 nm) laser system using a single fiber 'coupled' to a multiple array of fibers (4 to 6) has been developed for the delivery of low power laser irradiation to hepatic tissue. The advantage of laser energy being delivered simultaneously through multiple fibers is that it expands the area of tissue that can be treated over a given time. Through the use of interventional techniques including percutaneous ultrasound and/or CAT scan directed treatment, laser induced interstitial hyperthermia for large or multiple metastatic lesions could be initiated without the morbidity associated with open surgical procedures.

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Kenneth Eugene Bartels D.V.M., Mark H. Mellow, Marilyn Kostolich D.V.M., George A. Henry D.V.M., Bradley R. Barnes, Frederic M. Durville, Steven A. Schafer, Jerzy S. Krasinski, and Richard C. Powell "Development of procedures and instrumentation for use of the Nd:YAG laser in the ablation of metastases from colorectal cancer", Proc. SPIE 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III, (1 June 1992); https://doi.org/10.1117/12.137335

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KEYWORDS

Control systems

Fiber lasers

Laser tissue interaction

Nd:YAG lasers

Beam controllers

Colorectal cancer

Laser energy

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