Integrated optic sensor with macro-flow cell

Anthony A. Boiarski; James R. Busch; Ballwant S. Bhullar; Richard W. Ridgway; Van E. Wood

doi:10.1117/12.141217

2 March 1993 Integrated optic sensor with macro-flow cell

Anthony A. Boiarski, James R. Busch, Ballwant S. Bhullar, Richard W. Ridgway, Van E. Wood

Proceedings Volume 1793, Integrated Optics and Microstructures; (1993) https://doi.org/10.1117/12.141217
Event: Fibers '92, 1992, Boston, MA, United States

Abstract

An integrated-optic channel waveguide device is configured as a biosensor. The device measures a refractive index change on the waveguide surface, so it is called a biorefractometer. With an appropriate overlay or selective coating, the device can monitor proteins in blood or pollutants and bio-warfare agents in water. We describe the design, fabrication, and testing of a sensor employing a waveguide Mach-Zehnder interferometer configuration. The device is fabricated in a glass substrate using potassium ion exchange. A patterned glass buffer layer defines the sensing and reference arms of the interferometer. A silicone-rubber macro-flow cell confines the liquid above the integrated-optical waveguide device. Salt solution data show that the biorefractometer has a sensitivity ((Delta) n_eff/(Delta) n_Liquid) of 2 X 10^-3 and can measure refractive index changes of about 0.005. Data obtained for antigen-antibody binding of the protein IgG indicate that a 10 percent signal change occurs in approximately 1 minute for a 10 (mu) g/ml concentration level.

Citation Download Citation

Anthony A. Boiarski, James R. Busch, Ballwant S. Bhullar, Richard W. Ridgway, and Van E. Wood "Integrated optic sensor with macro-flow cell", Proc. SPIE 1793, Integrated Optics and Microstructures, (2 March 1993); https://doi.org/10.1117/12.141217

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