Investigation of therapeutics width in treatment of experimental cancer used by the model of medicine based on photosensitizer of second generation for PDT--aluminum sulfonated phthalocyanine

Victor E. Normansky; Maria G. Galpern

doi:10.1117/12.168703

1 March 1994 Investigation of therapeutics width in treatment of experimental cancer used by the model of medicine based on photosensitizer of second generation for PDT--aluminum sulfonated phthalocyanine

Victor E. Normansky, Maria G. Galpern

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168703
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Width of the therapeutic action of a drug model on the basis of aluminum sylphonated phthalocyanine -- photosensitizer of the second generation for PDT -- was investigated on laboratory mice with spontaneous breast tumor. Three general types of tumors were investigated in the process of morphological investigation: pleomorphic adenocarcinomas of type A and B, and monomorphic adenocarcinomas of type C. Different tumors local selectivity to the present photosensitizer was established by the microspectrofluorimetric method. The largest tumor accumulation selectivity, and also photosensitizer distribution uniformity, were revealed in a high-differentiation variant of pleomorphic adenocarcinomas of type B, which is more sensitive to PDT. It was experimentally determined that the combination of surface and interstitial irradiation is necessary in the overwhelming majority of cases.

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Victor E. Normansky and Maria G. Galpern "Investigation of therapeutics width in treatment of experimental cancer used by the model of medicine based on photosensitizer of second generation for PDT--aluminum sulfonated phthalocyanine", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168703

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