Photodynamic therapy of gastrointestinal cancers

Marie-Therese Foultier; Veronique Vonarx-Coinsmann; Yann Harel; S. Cordel; B. Antona; Thierry Patrice

doi:10.1117/12.168672

1 March 1994 Photodynamic therapy of gastrointestinal cancers

Marie-Therese Foultier, Veronique Vonarx-Coinsmann, Yann Harel, S. Cordel, B. Antona, Thierry Patrice

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168672
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

A new photosensitizer (PS), meso-tetrahydroxyphenyl-chlorin(m-THPC), has been clinically evaluated for photodynamic therapy (PDT) of early squamous cell carcinomas located in the upper aerodigestive tract, the oesophagus and the tracheobronchial tree. The injected doses ranged between 0.1 - 0.3 mg/kg m-THPC and the wavelength of the excitation light was either at 514 nm or 652 nm. The evaluation of the m-THPC induced phototoxicity was carried out on healthy mucosae of the bronchi, the oral cavity and the skone cell population to the other. Appearance of aneuploid populations after PDT suggests that destruction of sensitive cell populations allows the growth of initially non FCM detectable aneuploid clones. MDA assay could thus be a good prognostic tool although larger series of patients are needed. 115

Citation Download Citation

Marie-Therese Foultier, Veronique Vonarx-Coinsmann, Yann Harel, S. Cordel, B. Antona, and Thierry Patrice "Photodynamic therapy of gastrointestinal cancers", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168672

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