Possibilities and limitations in chemical modeling of the primary processes in photodynamic therapy

Tamas Vidoczy; Zsolt Kuti; Saleh Elzemzam; Dezso Gal

doi:10.1117/12.168702

1 March 1994 Possibilities and limitations in chemical modeling of the primary processes in photodynamic therapy

Tamas Vidoczy, Zsolt Kuti, Saleh Elzemzam, Dezso Gal

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168702
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

The reactivity of the triplet state photosensitizer (hematoporphyrin) has been studied in model systems (homogeneous solutions). Preliminary experiments show that stable free radicals are consumed during interactions with triplet hematoporphyrin. These results combined with data in the literature enable the calculation of the relative importance of the interaction between the free radical and the triplet sensitizer as compared to the energy transfer from the triplet to ground state oxygen producing singlet oxygen. Our data are confirmed by direct measurements on the quantum yield of singlet oxygen in the absence and in the presence of stable free radicals.

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Tamas Vidoczy, Zsolt Kuti, Saleh Elzemzam, and Dezso Gal "Possibilities and limitations in chemical modeling of the primary processes in photodynamic therapy", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168702

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