Fourier transform Raman spectroscopic studies of human and animal skins

Brian W. Barry; Howell G.M. Edwards; Adrian C. Williams

doi:10.1117/12.166802

31 January 1994 Fourier transform Raman spectroscopic studies of human and animal skins

Brian W. Barry, Howell G.M. Edwards, Adrian C. Williams

Proceedings Volume 2089, 9th International Conference on Fourier Transform Spectroscopy; (1994) https://doi.org/10.1117/12.166802
Event: Fourier Transform Spectroscopy: Ninth International Conference, 1993, Calgary, Canada

Abstract

The stratum corneum is the outermost layer of the skin and provides the principal barrier for the ingress of chemicals and environmental toxins into human and animal tissues. However, human skin has several advantages for the administration of therapeutic agents (transdermal drug delivery), but problems occur with the supply, storage, and biohazardous nature of human tissue. Hence, alternative animal tissues have been prepared to model drug diffusion across human skin but the molecular basis for comparison is lacking. Here, FT-Raman spectra of mammalian (human and pig) and reptilian (snake) skins have been obtained and the structural dissimilarities are correlated with drug diffusion studies across the tissues.

Citation Download Citation

Brian W. Barry, Howell G.M. Edwards, and Adrian C. Williams "Fourier transform Raman spectroscopic studies of human and animal skins", Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); https://doi.org/10.1117/12.166802

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