Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry

Lawrence M. Jordan; Frank A. DiBianca; Jeno I. Sebes M.D.; Donald B. Thomason; Herbert D. Zeman; Peter G. Davis; Dona Kambeyanda; Gao Li; Gunnar Lovhoiden

doi:10.1117/12.176567

26 May 1994 Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry

Lawrence M. Jordan, Frank A. DiBianca, Jeno I. Sebes M.D., Donald B. Thomason, Herbert D. Zeman, Peter G. Davis, Dona Kambeyanda, Gao Li, Gunnar Lovhoiden

Author Affiliations +

Proceedings Volume 2132, Clinical Applications of Modern Imaging Technology II; (1994) https://doi.org/10.1117/12.176567
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

A method utilizing digital dual-energy subtraction X-ray radiography for measuring calcium densities localized to the cortical and cancellous regions of bone cross sections is described. The method is being used to study calcium loss in femurs of two differently treated groups of rats. In each experimental cohort, one group of rats is restrained from weightbearing on hind limbs by suspension from a tail harness. The other (control) group is allowed normal weightbearing on all limbs. The densitometry data for each rat leg consists of six X-ray projection images acquired at roughly equal angles about the bone axis by an intensifying screen/CCD camera imaging system. Images of bone cross sections are reconstructed by application of a maximum entropy algorithm constrained by the six projection images. The observed density data are further discriminated into cortical, cancellous and external regions on the basis of reference levels found on image density histograms.

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Lawrence M. Jordan, Frank A. DiBianca, Jeno I. Sebes M.D., Donald B. Thomason, Herbert D. Zeman, Peter G. Davis, Dona Kambeyanda, Gao Li, and Gunnar Lovhoiden "Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry", Proc. SPIE 2132, Clinical Applications of Modern Imaging Technology II, (26 May 1994); https://doi.org/10.1117/12.176567

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KEYWORDS

Bone

Densitometry

Reconstruction algorithms

X-rays

Calcium

Image restoration

CCD cameras

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