Modern equilibrium ultracentrifugation: applications of automated interferometry

David A. Yphantis; Jeffrey W. Lary

doi:10.1117/12.180787

21 July 1994 Modern equilibrium ultracentrifugation: applications of automated interferometry

David A. Yphantis, Jeffrey W. Lary

Proceedings Volume 2136, Biochemical Diagnostic Instrumentation; (1994) https://doi.org/10.1117/12.180787
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

The development of automated interferometry for the ultracentrifuge is presented briefly, along with a short description of our current `real-time' acquisition system for equilibrium studies. Use of this system and of the associated data analyses techniques for both conventional and short solution column experiments of various types are discusses with emphasis on the application of nonlinear least squares fitting procedures. A brief summary is presented of the use of these approaches to detect and measure heterogeneity of various types.

Citation Download Citation

David A. Yphantis and Jeffrey W. Lary "Modern equilibrium ultracentrifugation: applications of automated interferometry", Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); https://doi.org/10.1117/12.180787

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