Interesting method for the synthesis of monofunctionalized phthalocyanines via subphthalocyanines for photodynamic therapy of cancer

Rainier G. Senz; Ralf Herter

doi:10.1117/12.199165

12 January 1995 Interesting method for the synthesis of monofunctionalized phthalocyanines via subphthalocyanines for photodynamic therapy of cancer

Rainier G. Senz, Ralf Herter

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199165
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The photodynamic therapy (PDT) of cancer is based on the reaction of dyes, light and oxygen in tumorous tissue. Currently, mainly two different photosensitizers [Photofrin II and Hematoporphyrine derivatives (HPD)] are used in clinical investigations. They are far from being ideal for this purpose as they do not have the required specificity and the absorption maxima do not lie in the ideal region of 760 nm (maximum transmission for human tissue). These properties could potentially be improved by monofunctionalization of the photosensitizers which would allow them to be coupled with tumor specific antibodies. Also, variation of the peripheric substituents would lead to a shift in the absorption maxima to a point nearer to 760 nm. By modification of the methods found in the literature it has been possible to synthesize two new subphthalocyanines and one new subnaphthalocyanine. Starting by reacting 3,6-Dihydroxyphthalicaciddinitrile, 3,6-Dibutyloxyphthalodi-nitrile or 2,3- Dicyanonaphthalene with boron trichloride in a solvent with a high boiling point, it has been possible to form the subphthalocyanines (I) and subnaphthalocyanine (II).

Citation Download Citation

Rainier G. Senz and Ralf Herter "Interesting method for the synthesis of monofunctionalized phthalocyanines via subphthalocyanines for photodynamic therapy of cancer", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199165

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available