Radio frequency needle hyperthermia of normal and cancerous animal tissue

Arieh Shalhav; J. Ramon; Benad Goldwasser; Ofer Nativ; Ramy Cherniack; Liliana Zajdel

doi:10.1117/12.197567

23 December 1994 Radio frequency needle hyperthermia of normal and cancerous animal tissue

Arieh Shalhav, J. Ramon, Benad Goldwasser, Ofer Nativ, Ramy Cherniack, Liliana Zajdel

Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197567
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Capacitative radio frequency (RF) was met with little success when used to treat human cancer. Conductive rf needle hyperthermia (RFNH) is used successfully for human tissue ablation in neurosurgery, cardiology, and recently in urology. RFNH ablates tissue by causing thermal damage limited to the vicinity of the rf needle. We conducted a series of studies to evaluate the effect of RFNH on cancerous and normal tissue. RFNH was applied to normal porcine livers during open surgery. Liver function tests were elevated two days post treatment, then returned to normal. Pigs were sequentially sacrificed. RFNH induced lesions were found to be maximal in size on days 2 - 4 post treatment and later became smaller as liver regenerated. Phase 2 included mice bearing two subcutaneous murine bladder tumors (MBT2). The rf needle was inserted into both tumors of each mouse, but rf current was applied to one tumor only. Energies of 3 to 7.5 watts were applied for 30 seconds to 5 minutes using a 0.02 inch needle. Mice were sacrificed 0, 1, and 3 days after treatment. Necrotic lesions 0.5 - 1.2 cm in diameter were found within the treated tumors. In phase 3, mice bearing a single 8 - 18 mm subcutaneous tumor were treated by RFNH aiming for complete tumor destruction. All control mice died of huge tumors within 31 days. Treated mice were alive with no signs of tumor when sacrificed 60 days after treatment. In phase 3 RFNH is capable of complete tumor eradication with little damage to surrounding normal tissue. It may have clinical applications for percutaneous endoscopic and laparoscopic treatment of tumors.

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Arieh Shalhav, J. Ramon, Benad Goldwasser, Ofer Nativ, Ramy Cherniack, and Liliana Zajdel "Radio frequency needle hyperthermia of normal and cancerous animal tissue", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197567

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KEYWORDS

Tumors

Tissues

Liver

Computed tomography

Laser applications

Medical laser equipment

Cancer

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