Endoscopic fluorescence of gastrointestinal neoplasia after sensitization with 5-aminolaevulinic acid (ALA) or Photofrin

Helmut Messmann; Peter Mlkvy; Sune Montan; Ingrid Wang-Nordman; Annika M.K. Nilsson; Katarina Svanberg M.D.; Sune Svanberg; Alexander J. MacRobert; Stephen G. Bown

doi:10.1117/12.203402

1 March 1995 Endoscopic fluorescence of gastrointestinal neoplasia after sensitization with 5-aminolaevulinic acid (ALA) or Photofrin

Helmut Messmann, Peter Mlkvy, Sune Montan, Ingrid Wang-Nordman, Annika M.K. Nilsson, Katarina Svanberg M.D., Sune Svanberg, Alexander J. MacRobert, Stephen G. Bown

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203402
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Fluorescence after photosensitization has the potential to identify lesions not visible on conventional endoscopy. We assessed 12 patients at high risk of or with established GI cancers (u ulcerative colitis, 1 colon polyp, 2 familial polyposis with duodenal polyps, 2 early oesophageal cancers). Fluorescence images (excitation 390 nm) were recorded with endoscopic equipment and additional spot measurements (optical multichannel analyzer). Patients were given 10 - 60 mg/kg ALA orally or 2 mg/kg Photofrin i.v. 60 mg/kg ALA gave high levels of PP IX (proto-porphyrin IX) in all areas, but 10 - 15 mg/kg resulted in selectivity in macroscopically inflamed colon. Photofrin gave oesophageal tumors selectivity at 4 and 48 hours. Photofrin patients subsequently had PDT. Photobleaching was documented in 3. We conclude that these techniques have potential as `optical biopsy tools' and for screening for early neoplastic changes.

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Helmut Messmann, Peter Mlkvy, Sune Montan, Ingrid Wang-Nordman, Annika M.K. Nilsson, Katarina Svanberg M.D., Sune Svanberg, Alexander J. MacRobert, and Stephen G. Bown "Endoscopic fluorescence of gastrointestinal neoplasia after sensitization with 5-aminolaevulinic acid (ALA) or Photofrin", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203402

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