Photodynamic therapy of the atherosclerotic abdominal aorta by laparoscopical approach using a pheophorbide derivative

Takashi Saito; Junichi Hayashi; Hideaki Sato; Hirofumi Kawabe; Katsuo Aizawa

doi:10.1117/12.203415

1 March 1995 Photodynamic therapy of the atherosclerotic abdominal aorta by laparoscopical approach using a pheophorbide derivative

Takashi Saito, Junichi Hayashi, Hideaki Sato, Hirofumi Kawabe, Katsuo Aizawa

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203415
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

A new photosensitizer, PH-1126, was administered intravenously into the ear vein of cholesterol-fed atherosclerotic rabbits at a dose of 1 mg/kg of body weight. At 24 hours after PH-1126 administration, the atherosclerotic lesions of the abdominal aorta were irradiated by krypton ion laser at 647 nm of wavelength with 100 J/cm². The abdominal aorta irradiated by laser beam was excised for histological analysis using the scanning electron microscopy and transmission electron microscopy. In the atherosclerotic plaque irradiated by krypton ion laser, migratory cells were observed and some of these cells were migrated into the lumen of the vessel. These findings suggested that these migratory cells from atherosclerotic plaque were foam cells destroyed by photodynamic therapy.

Citation Download Citation

Takashi Saito, Junichi Hayashi, Hideaki Sato, Hirofumi Kawabe, and Katsuo Aizawa "Photodynamic therapy of the atherosclerotic abdominal aorta by laparoscopical approach using a pheophorbide derivative", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203415

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