Sensitization and photodynamic therapy of esophageal, duodenal, and colonic tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrinIX (PPIX)

Peter Mlkvy; Helmut Messmann; Jaroslaw Regula; M. Conio; M. Pauer; Charles E. Millson; Alexander J. MacRobert; Stephen G. Bown

doi:10.1117/12.203379

1 March 1995 Sensitization and photodynamic therapy of esophageal,duodenal, and colonic tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX)

Peter Mlkvy, Helmut Messmann, Jaroslaw Regula, M. Conio, M. Pauer, Charles E. Millson, Alexander J. MacRobert, Stephen G. Bown

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203379
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Five aminolaevulinic acid (ALA) is a promising agent for PDT sensitization as it can be given orally and only causes skin photosensitivity for 1 - 2 days. In fluorescence and photodynamic studies 26 patients with benign and malignant gastrointestinal tumors (M 17, F 9; mean age 79) were given 30 - 60 mg ALA orally (single or divided doses) and biopsies taken of tumor and normal tissue at 1 - 24 hours for fluorescence microscopy. With 30 mg/kg, highest protoporphyrin IX (PPIX) levels were seen in oesophagus, duodenum and less in colon, but without tumor selectivity. Better tumor selectivity was seen in the colon after 60 mg/kg (5:1). Six patients had transient rises in transaminases and five mild nausea. Sixteen patients were later treated (after further ALA) with red light (628 nm, bare fiber or diffuser, 50 - 100 J at 50 mW at each site). All but two showed subsequent necrosis, but only 0.5 - 1.5 mm depth. PDT with ALA is simple, safe, and promising for tumors in the GI tract. Modification of treatment parameters may make it suitable for larger lesions.

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Peter Mlkvy, Helmut Messmann, Jaroslaw Regula, M. Conio, M. Pauer, Charles E. Millson, Alexander J. MacRobert, and Stephen G. Bown "Sensitization and photodynamic therapy of esophageal,duodenal, and colonic tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX)", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203379

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