Improved efficacy of SnET2 mediated PDT with the simultaneous application of selective hyperthermia

A. Charles Lytle; Dale D. Severson; Daniel R. Doiron; Charles J. Gomer; Angela Ferrario

doi:10.1117/12.208189

1 May 1995 Improved efficacy of SnET2 mediated PDT with the simultaneous application of selective hyperthermia

A. Charles Lytle, Dale D. Severson, Daniel R. Doiron, Charles J. Gomer, Angela Ferrario

Proceedings Volume 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV; (1995) https://doi.org/10.1117/12.208189
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

The results of experiments combining laser hyperthermia (LHT) wit photodynamic therapy (PDT) in the treatment of cancerous tumors have been very encouraging. Typically treatments have been sequential, employing separate hyperthermia and PDT systems. Sequential application of these therapies, however, fails to maximize the synergistic effects of combined, simultaneous treatment. This paper reports the results of an SBIR funded Phase I project intended to develop a system for precise simultaneous delivery of both LHT and PDT light, and to measure the synergistic effects os simultaneously applied LHT and PDT with both Photofrin II- and SnET2-mediated PDT. A system was developed that would allow the use to specify all treatment parameters and then deliver the combined light to the treatment site. Thermal and optical feedback in the system provide stability and precise control during the treatment. The system architecture, the computer control system, and the results obtained from bench-testing the system are presented in this paper. The system was then tested in a small animal tumor model. This paper will discuss the study protocol and the experimental results.

Citation Download Citation

A. Charles Lytle, Dale D. Severson, Daniel R. Doiron, Charles J. Gomer, and Angela Ferrario "Improved efficacy of SnET2 mediated PDT with the simultaneous application of selective hyperthermia", Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208189

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available