Adaptable three-dimensional Monte Carlo modeling of imaged blood vessels in skin

T. Joshua Pfefer; Jennifer Kehlet Barton; Eric K. Chan; Mathieu G. Ducros; Brian S. Sorg; Thomas E. Milner; J. Stuart Nelson M.D.; Ashley J. Welch

doi:10.1117/12.275468

16 June 1997 Adaptable three-dimensional Monte Carlo modeling of imaged blood vessels in skin

T. Joshua Pfefer, Jennifer Kehlet Barton, Eric K. Chan, Mathieu G. Ducros, Brian S. Sorg, Thomas E. Milner, J. Stuart Nelson M.D., Ashley J. Welch

Author Affiliations +

Proceedings Volume 2975, Laser-Tissue Interaction VIII; (1997) https://doi.org/10.1117/12.275468
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

In order to reach a higher level of accuracy in simulation of port wine stain treatment, we propose to discard the typical layered geometry and cylindrical blood vessel assumptions made in optical models and use imaging techniques to define actual tissue geometry. Two main additions to the typical 3D, weighted photon, variable step size Monte Carlo routine were necessary to achieve this goal. First, optical low coherence reflectometry (OLCR) images of rat skin were used to specify a 3D material array, with each entry assigned a label to represent the type of tissue in that particular voxel. Second, the Monte Carlo algorithm was altered so that when a photon crosses into a new voxel, the remaining path length is recalculated using the new optical properties, as specified by the material array. The model has shown good agreement with data from the literature. Monte Carlo simulations using OLCR images of asymmetrically curved blood vessels show various effects such as shading, scattering-induced peaks at vessel surfaces, and directionality-induced gradients in energy deposition. In conclusion, this augmentation of the Monte Carlo method can accurately simulate light transport for a wide variety of nonhomogeneous tissue geometries.

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T. Joshua Pfefer, Jennifer Kehlet Barton, Eric K. Chan, Mathieu G. Ducros, Brian S. Sorg, Thomas E. Milner, J. Stuart Nelson M.D., and Ashley J. Welch "Adaptable three-dimensional Monte Carlo modeling of imaged blood vessels in skin", Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); https://doi.org/10.1117/12.275468

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