Optical Doppler tomography for noninvasive imaging of in-vivo blood flow

Zhongping Chen; Thomas E. Milner; Shyam M. Srinivas; Tore Lindmo; Digant P. Dave; J. Stuart Nelson M.D.

doi:10.1117/12.274308

22 May 1997 Optical Doppler tomography for noninvasive imaging of in-vivo blood flow

Zhongping Chen, Thomas E. Milner, Shyam M. Srinivas, Tore Lindmo, Digant P. Dave, J. Stuart Nelson M.D.

Proceedings Volume 2981, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications; (1997) https://doi.org/10.1117/12.274308
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

We report the development of an optical technique for noninvasive in vivo imaging of tissue structure and blood flow dynamics with high spatial resolution (2 - 15 micrometer) in biological systems. The technique is based on coherence optical Doppler tomography (ODT), which combines Doppler velocimetry with optical coherence tomography to measure blood flow velocity at discrete spatial locations. The exceptionally high resolution of ODT allows noninvasive in vivo imaging of both blood microcirculation and tissue structures surrounding the vessel, which has significance for biomedical research and clinical applications. Tomographic velocity imaging of in vivo blood flow in a rat mesentery is demonstrated.

Citation Download Citation

Zhongping Chen, Thomas E. Milner, Shyam M. Srinivas, Tore Lindmo, Digant P. Dave, and J. Stuart Nelson M.D. "Optical Doppler tomography for noninvasive imaging of in-vivo blood flow", Proc. SPIE 2981, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications, (22 May 1997); https://doi.org/10.1117/12.274308

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