Time-resolved reflectance spectroscopy in tissues

Rinaldo Cubeddu; Antonio Pifferi; Paola Taroni; Alessandro Torricelli; Gianluca Valentini

doi:10.1117/12.350038

14 June 1999 Time-resolved reflectance spectroscopy in tissues

Rinaldo Cubeddu, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Gianluca Valentini

Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.350038
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

A system for the measurement of absorption and scattering spectra of turbid media in a wide spectral range based on time-resolved reflectance spectroscopy is described. The system operates with tunable mode-locked lasers, and an electronic chain for time-correlated single-photon counting. Laser tuning and optimization, acquisition, and data analysis are fully automated so as to allow in vivo spectroscopy of human tissues within a reasonable measurement time. Absorption and transport scattering spectra were acquired from 610 nm up to 1010 nm every 5 nm on different tissues of healthy volunteers. Examples of the female breast as well as of the human forearm and abdomen are presented, showing a high inter- subject variability. Finally, the measured absorption and scattering values are used to calculate the penetration depth of light in the same tissues.

Citation Download Citation

Rinaldo Cubeddu, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, and Gianluca Valentini "Time-resolved reflectance spectroscopy in tissues", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); https://doi.org/10.1117/12.350038

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