Fluorescence lifetime imaging for biomedicine using all-solid state ultrafast laser technology

Richard Jones; Keith Dowling; Mary J. Cole; Duncan Parsons-Karavassilis; Paul M. W. French; M. John Lever; Jonathan D. Hares; Anthony K. L. Dymoke-Bradshaw

doi:10.1117/12.351824

4 June 1999 Fluorescence lifetime imaging for biomedicine using all-solid state ultrafast laser technology

Richard Jones, Keith Dowling, Mary J. Cole, Duncan Parsons-Karavassilis, Paul M. W. French, M. John Lever, Jonathan D. Hares, Anthony K. L. Dymoke-Bradshaw

Author Affiliations +

Proceedings Volume 3616, Commercial and Biomedical Applications of Ultrafast Lasers; (1999) https://doi.org/10.1117/12.351824
Event: Optoelectronics '99 - Integrated Optoelectronic Devices, 1999, San Jose, CA, United States

Abstract

We present potential biomedical applications for a diode- pumped ultrafast Cr:LiSGAF oscillator-amplifier system. A whole-field fluorescence lifetime imaging system has been demonstrated for the first time using such a laser system. Fluorescence lifetime imaging of unstained biological tissue in vitro using this instrument has shown contrast between different tissue constituents. Initial results of applying this laser system to the ablation of glass are also presented.

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Richard Jones, Keith Dowling, Mary J. Cole, Duncan Parsons-Karavassilis, Paul M. W. French, M. John Lever, Jonathan D. Hares, and Anthony K. L. Dymoke-Bradshaw "Fluorescence lifetime imaging for biomedicine using all-solid state ultrafast laser technology", Proc. SPIE 3616, Commercial and Biomedical Applications of Ultrafast Lasers, (4 June 1999); https://doi.org/10.1117/12.351824

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