This work incorporates development of a model that relates 3-D arrangement of breast tissue and its appearance in a mammogram. The primary contribution is modeling breast structures based on their anatomic properties, obtained from the literature and histologic slice images. Additionally, breast compression deformation is estimated using tissue elastic properties and a deformation model. Synthetic mammograms obtained by the proposed approach can be used in analysis of positioning and compression effects, and for testing computer algorithms for detection of abnormalities. The paper discusses three major model components: (1) modeling breast anatomic structures, (2) modeling breast tissue compression, and (3) modeling X-ray image acquisition.
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