Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume

Masamitsu Haruna; Masato Ohmi; Mitsuo Nakamura; Shigeto Morimoto

doi:10.1117/12.382719

19 April 2000 Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume

Masamitsu Haruna, Masato Ohmi, Mitsuo Nakamura, Shigeto Morimoto

Author Affiliations +

Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382719
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We demonstrate the nanosecond time-gated spectroscopy of plume in laser ablation of biological tissue, which allows us to detect calcium (Ca) with high sensitivity by the use of either a UV or a near-IR laser pulse. Clear and sharp peaks of Ca⁺ appear in the luminescence spectrum of laser-ablation plume although the Ca content is only 0.1 percent in human hair and nail. Luminescence peaks of sodium atom (Na) and ionized carbon are also detectable. This specific spectroscopy is low invasive because a single low-energy laser pulse illuminates the tissue sample, and it does not require any poisonous sensititizers like fluorescence dye. This method, therefore, is a promising candidate for optical biopsy in the near future. In particular, Ca detection of human hair may lead to new diagnosis, including monitor of daily intake of Ca and a screening diagnosis of osteoporosis.

Citation Download Citation

Masamitsu Haruna, Masato Ohmi, Mitsuo Nakamura, and Shigeto Morimoto "Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382719

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