Minimally invasive ultrasound thermal therapy with MR thermal monitoring and guidance

Chris J. Diederich; R. Jason Stafford; Roger E. Price D.V.M.; William H. Nau; Per Daniel Tyreus; Belinda Rivera; Donald Schomer; Lars Olsson; John D. Hazle

doi:10.1117/12.427856

1 June 2001 Minimally invasive ultrasound thermal therapy with MR thermal monitoring and guidance

Chris J. Diederich, R. Jason Stafford, Roger E. Price D.V.M., William H. Nau, Per Daniel Tyreus, Belinda Rivera, Donald Schomer, Lars Olsson, John D. Hazle

Author Affiliations +

Proceedings Volume 4247, Thermal Treatment of Tissue: Energy Delivery and Assessment; (2001) https://doi.org/10.1117/12.427856
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

In this study both transurethral and interstitial ultrasound thermal therapy were applied to thermally coagulate targeted portions of the canine prostate or brain and implanted TVT tumors while using MRI-based thermal mapping techniques to monitor the therapy. MRI was also used for target definition, positioning of the applicator, and evaluation of target viability post-therapy. The complex phase-difference mapping technique using an iGE-EPI sequence with lipid suppression was used for determining temperature elevations within the in vivo prostate or brain and surrounding structures. Calculated temperature distributions, thermal dose exposures, T2-wieghted & T1-contrast enhanced images, gross inspection, and histology of sectioned prostates and brains were in good agreement with each other in defining destroyed tissue zones. Interstitial and transurethral ultrasound applicators produce directed zones of thermal coagulation within targeted tissue and implanted tumor, which can be accurately monitored and evaluated by MRI.

Citation Download Citation

Chris J. Diederich, R. Jason Stafford, Roger E. Price D.V.M., William H. Nau, Per Daniel Tyreus, Belinda Rivera, Donald Schomer, Lars Olsson, and John D. Hazle "Minimally invasive ultrasound thermal therapy with MR thermal monitoring and guidance", Proc. SPIE 4247, Thermal Treatment of Tissue: Energy Delivery and Assessment, (1 June 2001); https://doi.org/10.1117/12.427856

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