Bone microstructure deformation observed by Raman microscopy

Michael D. Morris; Angela Carden; Rupak M. Rajachar; David H. Kohn

doi:10.1117/12.427949

4 June 2001 Bone microstructure deformation observed by Raman microscopy

Michael D. Morris, Angela Carden, Rupak M. Rajachar, David H. Kohn

Proceedings Volume 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III; (2001) https://doi.org/10.1117/12.427949
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

While many macroscopic approaches have been used to study bone's mechanical properties, little is known about the effect of mechanical stresses on bone tissue at the microstructural and submicrostructural levels. Raman microspectroscopy has been found to be an extremely sensitive technique for examining the effects of mechanical loading on polymer structures and thin films, as well as for the study of protein conformations. We present the first application of this technique to bone tissue. The organic component of bone is a highly ordered matrix composed mainly of collagen fibrils. Stress upon the bone tissue creates disorder in this structure; this disorder can easily be detected by Raman spectroscopy. Small changes in the matrix structure manifest themselves as band shifts in the Raman spectra.

Citation Download Citation

Michael D. Morris, Angela Carden, Rupak M. Rajachar, and David H. Kohn "Bone microstructure deformation observed by Raman microscopy", Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); https://doi.org/10.1117/12.427949

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