Noninvasive in-vivo tissue-modulated Raman spectroscopy of human blood: microcirculation and viscosity effects

Joseph Chaiken; William F. Finney; Paul E. Knudson; Karen P. Peterson; Charles M. Peterson; Xiaoke Yang; Ruth S. Weinstock

doi:10.1117/12.427952

4 June 2001 Noninvasive in-vivo tissue-modulated Raman spectroscopy of human blood: microcirculation and viscosity effects

Joseph Chaiken, William F. Finney, Paul E. Knudson, Karen P. Peterson, Charles M. Peterson, Xiaoke Yang, Ruth S. Weinstock

Author Affiliations +

Proceedings Volume 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III; (2001) https://doi.org/10.1117/12.427952
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and then normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. A more careful comparison of tissue modulated spectra with static in vitro and invasive in vivo spectra suggests that there are small microcirculation differences between individuals resulting in some variability in their noninvasive quantitation. This variability is based on the mechanism for blood volume normalization and various means for obtaining necessary corrections are suggested. We present new clinical data from individuals and groups supporting this mechanism and suggesting how such measurements might also be used to quantify various microcirculation abnormalities.

Citation Download Citation

Joseph Chaiken, William F. Finney, Paul E. Knudson, Karen P. Peterson, Charles M. Peterson, Xiaoke Yang, and Ruth S. Weinstock "Noninvasive in-vivo tissue-modulated Raman spectroscopy of human blood: microcirculation and viscosity effects", Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); https://doi.org/10.1117/12.427952

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