Deep tomography of biological tissues by optoacoustic method

Alexander M. Reyman; Ivan V. Yakovlev; Alexey G. Kirillov; Vladimir V. Lozhkarev

doi:10.1117/12.429303

15 June 2001 Deep tomography of biological tissues by optoacoustic method

Alexander M. Reyman, Ivan V. Yakovlev, Alexey G. Kirillov, Vladimir V. Lozhkarev

Proceedings Volume 4256, Biomedical Optoacoustics II; (2001) https://doi.org/10.1117/12.429303
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The results of theoretical and experimental investigations of pulsed optoacoustic (OA) method for tomography of biological objects in the frequency range 1-10 MHz at the depths of up to 5 centimeters are presented. Some key imaging problems - reducing of effect of surface OA pulse and light shock on the received signal, enhancing of the uniformity of light distribution inside the object keeping light irradiation at the reliable level - can be solved by choice of experiment configuration and spatial scanning. Taking into account distortions of OA signal due to frequency dependence of tissue properties and receiving/amplifying circuits the acoustical source position can be found using signal processing e.g. inverse filtering algorithm. The next step to the high-quality imaging is in use of reconstructive tomographic algorithms. The experimental setup was designed for OA tomographic investigation of phantoms (artificial objects and biotissue samples) as well as in vivo objects. The received signals were amplified, digitized and stored in PC. The experiments with the model objects were carried out to elaborate principles of multichannel receiving by weakly-directed probes and to study the methods for reconstruction of 2D tomograms. The results show that post-processing and choice of experiment geometry allow to improve significantly the quality of optoacoustic tomograms. This work was supported by RFBR (Project #00-02-16600).

Citation Download Citation

Alexander M. Reyman, Ivan V. Yakovlev, Alexey G. Kirillov, and Vladimir V. Lozhkarev "Deep tomography of biological tissues by optoacoustic method", Proc. SPIE 4256, Biomedical Optoacoustics II, (15 June 2001); https://doi.org/10.1117/12.429303

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