Clinical study assessing the photosensitizer accumulation and light penetration for esophageal cancer prior to treatment by PDT

Paulo R. Bargo; Steven L. Jacques

doi:10.1117/12.434744

9 July 2001 Clinical study assessing the photosensitizer accumulation and light penetration for esophageal cancer prior to treatment by PDT

Paulo R. Bargo, Steven L. Jacques

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Proceedings Volume 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical; (2001) https://doi.org/10.1117/12.434744
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The FDA has approved PDT using Photofrin for certain esophageal and lung cancers, specifying an approved prescription of administered drug (mg/kg body weight) and administered light (J/linear cm of cylindrical fiber). This paper describes our development of a multi-optical fiber catheter for endoscopic use which documents the drug accumulated in the target tissues and the light penetration into the target tissues. The catheter uses reflectance to specify the light penetration depth and uses reflectance- corrected fluorescence to document drug accumulation. The goal is to document the variation in drug and light received by patients who are administered the FDA-approved prescription.

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Paulo R. Bargo and Steven L. Jacques "Clinical study assessing the photosensitizer accumulation and light penetration for esophageal cancer prior to treatment by PDT", Proc. SPIE 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, (9 July 2001); https://doi.org/10.1117/12.434744

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KEYWORDS

Tissues

Tumors

Luminescence

Optical fibers

Reflectivity

Absorption

Photodynamic therapy

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