Monitoring of deep structures using a frequency-domain technique: experimental approaches

Andrei Dergatchev; Frits F. M. de Mul

doi:10.1117/12.429337

13 June 2001 Monitoring of deep structures using a frequency-domain technique: experimental approaches

Andrei Dergatchev, Frits F. M. de Mul

Proceedings Volume 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring; (2001) https://doi.org/10.1117/12.429337
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Aiming at development of tools for accurate non-invasive diagnosis, we investigate the accuracy of experimental and numerical approaches for monitoring of deep structures, such as blood vessels, together with determination of their optical parameters. Among numerical techniques developed for determination of structure and optical parameters of biotissue basing on measurement data, Monte Carlo simulations is the best tool, but requires a considerable computation time to preserve accuracy when one deals with large source detector separations. In contrast, diffusion approximation is fast but suffers from a difficulty of estimation of accuracy. We implemented an intermediate approach, deriving and solving frequency-domain-specific equations basing on radiative transfer theory. We conducted measurements and corresponding simulations using multilayered tissue-simulating sample and estimate accuracy novel techniques can achieve. We obtained an accuracy of 0.002 mm^-1 in measurements of the reduced scattering coefficient.

Citation Download Citation

Andrei Dergatchev and Frits F. M. de Mul "Monitoring of deep structures using a frequency-domain technique: experimental approaches", Proc. SPIE 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring, (13 June 2001); https://doi.org/10.1117/12.429337

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