Interferometric detection of laser-induced microbubbles in the retinal pigment epithelium

Joerg Neumann; Ralf Brinkmann

doi:10.1117/12.446505

26 October 2001 Interferometric detection of laser-induced microbubbles in the retinal pigment epithelium

Joerg Neumann, Ralf Brinkmann

Proceedings Volume 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy; (2001) https://doi.org/10.1117/12.446505
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

We developed an interferometric technique in order to detect microbubble formation within porcine retinal pigment epithelial (RPE) cells ex vivo after short pulsed laser exposure (527nm, 350ns). The irradiated surface of the RPE tissue samples was monitored by a Michelson interferometer. The obtained interferometric transients revealed bubble dynamics and were compared to optoacoustic transients recorded simultaneously. This interferometric technique might be useful for in vivo dosimetry during selective RPE-treatment.

Citation Download Citation

Joerg Neumann and Ralf Brinkmann "Interferometric detection of laser-induced microbubbles in the retinal pigment epithelium", Proc. SPIE 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy, (26 October 2001); https://doi.org/10.1117/12.446505

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