Approach to sequence DNA without tagging

Sanjun Niu; Ravi F. Saraf

doi:10.1117/12.446773

23 October 2001 Approach to sequence DNA without tagging

Sanjun Niu, Ravi F. Saraf

Proceedings Volume 4512, Complex Adaptive Structures; (2001) https://doi.org/10.1117/12.446773
Event: Complex Adaptive Structures, 2001, Hutchinson Island, FL, United States

Abstract

A concept to sequence DNA without tagging the molecule is developed. The fabrication process is compatible with current microelectronics and (emerging) soft-material fabrication technologies, allowing the method to be integrable with MEMS and lab-on-a-chip devices. The preliminary results indicate sensitivity in the nano-gram regime for 100 micron-square pixels. The technology can be extended to perform combinatorial analysis with on-line measurement in real-time during the hybridization process.

Citation Download Citation

Sanjun Niu and Ravi F. Saraf "Approach to sequence DNA without tagging", Proc. SPIE 4512, Complex Adaptive Structures, (23 October 2001); https://doi.org/10.1117/12.446773

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