Microfluidic sample preparation for immunoassays

Steven R. Visuri; William J. Benett; Kerry Bettencourt; John Chang; Karl A. Fisher; Julia Hamilton; Peter A. Krulevitch; Christina S. Park; Cheryl A. Stockton; Lisa A. Tarte; Amy Wang; Thomas Wilson

doi:10.1117/12.443043

28 September 2001 Microfluidic sample preparation for immunoassays

Steven R. Visuri, William J. Benett, Kerry Bettencourt, John Chang, Karl A. Fisher, Julia Hamilton, Peter A. Krulevitch, Christina S. Park, Cheryl A. Stockton, Lisa A. Tarte, Amy Wang, Thomas Wilson

Author Affiliations +

Proceedings Volume 4560, Microfluidics and BioMEMS; (2001) https://doi.org/10.1117/12.443043
Event: Micromachining and Microfabrication, 2001, San Francisco, CA, United States

Abstract

Researchers at Lawrence Livermore National Laboratory are developing means to collect and identify fluid-based biological pathogens in the forms of proteins, viruses, and bacteria. To support detection instruments, we are developing a flexible fluidic sample preparation unit. The overall goal of this Microfluidic Module is to input a fluid sample, containing background particulates and potentially target compounds, and deliver a processed sample for detection. We are developing techniques for sample purification, mixing, and filtration that would be useful to many applications including immunologic and nucleic acid assays. Many of these fluidic functions are accomplished with acoustic radiation pressure or dielectrophoresis. We are integrating these technologies into packaged systems with pumps and valves to control fluid flow through the fluidic circuit.

Citation Download Citation

Steven R. Visuri, William J. Benett, Kerry Bettencourt, John Chang, Karl A. Fisher, Julia Hamilton, Peter A. Krulevitch, Christina S. Park, Cheryl A. Stockton, Lisa A. Tarte, Amy Wang, and Thomas Wilson "Microfluidic sample preparation for immunoassays", Proc. SPIE 4560, Microfluidics and BioMEMS, (28 September 2001); https://doi.org/10.1117/12.443043

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