Study of photo-induced acoustic spectra of biological tissues and photoacoustic tomography by phase-controlled focus algorithm

Da Xing; Shengyou Qian

doi:10.1117/12.446637

25 October 2001 Study of photo-induced acoustic spectra of biological tissues and photoacoustic tomography by phase-controlled focus algorithm

Da Xing, Shengyou Qian

Author Affiliations +

Proceedings Volume 4597, Biophotonics Instrumentation and Analysis; (2001) https://doi.org/10.1117/12.446637
Event: International Symposium on Photonics and Applications, 2001, Singapore, Singapore

Abstract

In this paper, spectrospopic feature of photo-induced acoustic signal generated in biological tissues are investigated, and its characteristics are analyzed in time domain and in frequency domain. The results show that spectrum of photoacoustic signal changes with the property of medium sensitively. The frequency range of photoacoustic signal generated in biological tissues is about 2MHz, and its time duration is about 2microsecond(s) . According to the characteristics of photoacoustic signal, we present an experiment result of a photoacoustic tomography to depths of ~7mm for a real tissue, using a 532-nm pulse YAG laser. The time-resolved stress detection technique was used for PA signal detection and a spatial resolution up to 0.1mm was obtained. A phase-controlled focus algorithm was used for image reconstruction. Images of different depth profile of tissue was obtained with a depth resolution of ~20micrometers .

Citation Download Citation

Da Xing and Shengyou Qian "Study of photo-induced acoustic spectra of biological tissues and photoacoustic tomography by phase-controlled focus algorithm", Proc. SPIE 4597, Biophotonics Instrumentation and Analysis, (25 October 2001); https://doi.org/10.1117/12.446637

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KEYWORDS

Tissues

Acoustics

Signal detection

Photoacoustic spectroscopy

Sensors

Reconstruction algorithms

Photoacoustic tomography

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