Transdermal delivery of photosensitizer by laser-induced stress wave

Makoto Ogura; Shunichi Sato; Masahiko Kuroki; Hitoshi Wakisaka; Satoko Kawauchi; Miya Ishihara; Makoto Kikuchi; Masahiko Yoshioka; Hiroshi Ashida; Minoru Obara

doi:10.1117/12.432076

17 June 2002 Transdermal delivery of photosensitizer by laser-induced stress wave

Makoto Ogura, Shunichi Sato, Masahiko Kuroki, Hitoshi Wakisaka, Satoko Kawauchi, Miya Ishihara, Makoto Kikuchi, Masahiko Yoshioka, Hiroshi Ashida, Minoru Obara

Author Affiliations +

Proceedings Volume 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII; (2002) https://doi.org/10.1117/12.432076
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The skin permeability of most of drugs is low, because the stratum corneum works as a solid barrier. It is required, therefore, to enhance the skin permeability for transdermal delivery of drug. To investigate the effects of heating skin and exposing skin to a laser-induced stress wave (LISW) on the drug permeability, we tried to deliver porfimer sodium into rat’s skin. The experiment was performed under the four different skin conditions; exposing to a LISW (case 1); heating (case 2); exposing to a LISW and heating (case 3); control (case 4). It was observed in all cases except the case 4 (control), the drug permeated into the dermis through the epidermis. The deepest penetration was obtained in the case 3 (a LISW plus heating). It was suggested that heating increased the fluidity of the lipid bilayers in the stratum corneum, and therefore the drug permeability might be enhanced.

Citation Download Citation

Makoto Ogura, Shunichi Sato, Masahiko Kuroki, Hitoshi Wakisaka, Satoko Kawauchi, Miya Ishihara, Makoto Kikuchi, Masahiko Yoshioka, Hiroshi Ashida, and Minoru Obara "Transdermal delivery of photosensitizer by laser-induced stress wave", Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); https://doi.org/10.1117/12.432076

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