Interferometric fiber-based optical biosensor to measure ultra-small changes in refractive index

Taner Akkin; Digant P. Dave; Thomas E. Milner; Henry Grady Rylander III

doi:10.1117/12.463805

26 March 2002 Interferometric fiber-based optical biosensor to measure ultra-small changes in refractive index

Taner Akkin, Digant P. Dave, Thomas E. Milner, Henry Grady Rylander III

Proceedings Volume 4616, Optical Fibers and Sensors for Medical Applications II; (2002) https://doi.org/10.1117/12.463805
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

In many bio-medical optical imaging applications such as monitoring cell and tissue dynamics and imaging of phase objects, ultra-small changes in refractive index must be detected. We describe a fiber-based optical biosensor, which is capable of detecting ultra-small refractive index changes in highly scattering media with high lateral and longitudinal spatial resolution. The system is a dual channel phase-sensitive optical low coherence tomography system that measures relative optical path length differences between the orthogonal modes of the polarization-maintaining fiber.

Citation Download Citation

Taner Akkin, Digant P. Dave, Thomas E. Milner, and Henry Grady Rylander III "Interferometric fiber-based optical biosensor to measure ultra-small changes in refractive index", Proc. SPIE 4616, Optical Fibers and Sensors for Medical Applications II, (26 March 2002); https://doi.org/10.1117/12.463805

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