Perturbative theory of the electro-optic response of second-harmonic generation membrane potential sensors

Jerome Mertz; Laurent Moreaux; T. Pons

doi:10.1117/12.470691

17 June 2002 Perturbative theory of the electro-optic response of second-harmonic generation membrane potential sensors

Jerome Mertz, Laurent Moreaux, T. Pons

Proceedings Volume 4620, Multiphoton Microscopy in the Biomedical Sciences II; (2002) https://doi.org/10.1117/12.470691
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Second-harmonic generation microscopy is a promising tool for the visualization of biological membrane potentials with push-pull chromophores. We describe a response mechanism based on the electric field modulation of chromophore first hyperpolarizabilities. Our model approximates the chromophores as two level systems that incur charge shifts upon optical excitation.

Citation Download Citation

Jerome Mertz, Laurent Moreaux, and T. Pons "Perturbative theory of the electro-optic response of second-harmonic generation membrane potential sensors", Proc. SPIE 4620, Multiphoton Microscopy in the Biomedical Sciences II, (17 June 2002); https://doi.org/10.1117/12.470691

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