Resonant cavity optical biosensors for the detection of nucleic acid hybridization

Marc B. Airola; Steve Blair; Yan Chen; Jack Davis; Layne D. Williams

doi:10.1117/12.469793

4 June 2002 Resonant cavity optical biosensors for the detection of nucleic acid hybridization

Marc B. Airola, Steve Blair, Yan Chen, Jack Davis, Layne D. Williams

Proceedings Volume 4625, Clinical Diagnostic Systems: Technologies and Instrumentation; (2002) https://doi.org/10.1117/12.469793
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Optical microcavities can be used to enhance the detection sensitivity of evanescent-wave fluorescence biosensors to the binding of a labeled analyte to a biospecific monolayer. The enhancement results form the buildup of intensity within the microcavity on resonance, which thereby increases fluorescence output from species specifically bound on the surface of the microcavity. Target studies are directed at nucleic acid hybridization, and initial results using high-Q dielectric microspheres have been obtained.

Citation Download Citation

Marc B. Airola, Steve Blair, Yan Chen, Jack Davis, and Layne D. Williams "Resonant cavity optical biosensors for the detection of nucleic acid hybridization", Proc. SPIE 4625, Clinical Diagnostic Systems: Technologies and Instrumentation, (4 June 2002); https://doi.org/10.1117/12.469793

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