Intravascular Application Of Hematoporphyrin Derivative Photodynamic Therapy

Artur M. Spokojny; Donna Bourgelais; Juan R. Serur; S. Paulin; J.Richard Spears

doi:10.1117/12.943910

24 October 1984 Intravascular Application Of Hematoporphyrin Derivative Photodynamic Therapy

Artur M. Spokojny, Donna Bourgelais, Juan R. Serur, S. Paulin, J.Richard Spears

Proceedings Volume 0494, Novel Optical Fiber Techniques for Medical Applications; (1984) https://doi.org/10.1117/12.943910
Event: 28th Annual Technical Symposium, 1984, San Diego, United States

Abstract

Photodynamic therapy (PDT) of diseased tissues with hematoporphyrin derivative (HPD) within the cardiovascular system could be performed with a light-emitting antra-arterial optical fiber. However, the penetration of light at 631 nm through oxygenated whole blood first needs to be studied. In vitro studies were, therefore, performed to measure the transmission of 631 nm light, generated by an argon-ion pumped dye laser, through whole blood and serial dilutions of whole blood with the relatively translucent blood substitute Fluosol-DA. The results indicate that whole blood attenuates 631 nm light far greater than tissues, where HPD-PDT is currently applied, and that a 2 mm thickness of whole blood at a normal hematocrit may prevent a photodynamic tissue reaction when a conventional light dose is applied. Preliminary observations in rabbits treated in vivo with hematoporphyrin and 631 nm light via an intra-aortic optical fiber, with and without Fluosol-DA hemodilution, confirm these results. Hemodilution of whole blood with translucent liquids will enhance photodynamic tissue reactions and may be a necessary adjunct when this therapy is applied within the cardiovascular system.

Citation Download Citation

Artur M. Spokojny, Donna Bourgelais, Juan R. Serur, S. Paulin, and J.Richard Spears "Intravascular Application Of Hematoporphyrin Derivative Photodynamic Therapy", Proc. SPIE 0494, Novel Optical Fiber Techniques for Medical Applications, (24 October 1984); https://doi.org/10.1117/12.943910

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available